SAHMRI is proud to be partnering with SA Health and the Murdoch Children’s Research Institute (MCRI) in a clinical trial of a vaccine that could provide an immune system boost to protect against the worst of COVID-19’s symptoms.
What is the BRACE Trial?
The BCG vaccination to Reduce the impact of COVID-19 in Australian healthcare workers following Coronavirus Exposure (BRACE) Trial is a multi-centre randomised controlled clinical trial of the BCG vaccine against COVID-19.
The trial aims to enrol 10,000 healthcare workers from across Australia and Europe to investigate whether an existing, commonly-used vaccine can reduce the effects of COVID-19 infection.
What is BCG?
Bacillus Calmette-Guerin (BCG) is a vaccine that was developed against tuberculosis and is still given to more than 100 million babies annually for that purpose. It’s also commonly used as a treatment for people with bladder cancer.
There is epidemiological evidence that BCG vaccination could reduce susceptibility to respiratory infections such as COVID-19.
Previous studies have shown BCG reduces the level of virus when people are infected with other viruses. The vaccine also boosts people’s ‘frontline’ immunity, training it to respond to other subsequent infections with greater intensity. Researchers hope this improved ‘innate’ immunity will provide crucial time to develop and importantly, validate, a specific anti-SARS-CoV-2 vaccine.
SAHMRI is well placed to lead this trial in South Australia as, under the direction of Professor David Lynn, the institute has been researching the non-specific effects of vaccines including BCG.
In SA, healthcare workers employed by the Royal Adelaide Hospital and Women's and Children's Hospital will initially be invited to participate in the BRACE trial. Recruitment is underway already at the RAH and should begin shortly at the WCH.
Healthcare workers who have already had a flu shot can now participate in the trial.
Please enrol or register for the trial via the MCRI webpage.
For further information contact BRACE.email@example.com